Abstract Library

#3053 The Splicing Machinery Is Dysregulated in Low Grade Pulmonary Neuroendocrine Tumors

Introduction: Alternative splicing dysregulation is increasingly regarded as a novel cancer hallmark influencing all key tumor features. We have shown that neuroendocrine tumors (NETs) overexpress aberrantly spliced variants of neuropeptides and receptors that increase tumor malignancy. More recently, we discovered that the splicing machinery is dysregulated in pituitary and pancreatic NETs. To date, the status of this machinery in low grade pulmonary NETs is largely unknown.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author: Blázquez-Encinas R

Authors: Blázquez-Encinas R, Caro M, Pedraza-Arévalo S, Alors-Pérez E, Herrera-Martínez A,

Keywords: low grade pulmonary NETs, splicing, splicing machinery, malignancy,

#2846 Whole Genome DNA Methylation Profiling Identifies Neuroendocrine Tumor Origin

Introduction: Determining the origin of a neuroendocrine tumor (NET) of unknown primary can be challenging. Liver metastases can originate from any organ in the body, while pulmonary NETs can be metastases but also primary tumors. This especially holds true for Multiple Endocrine Neoplasia Type 1 patients, who often have multiple primary pancreatic and intestinal NETs. It is important to know the origin of the primary tumor since resection or ablation is crucial in case of treatment with curative intent. Furthermore, the site of origin determines prognosis, treatment options and eligibility for clinical trials.

Conference: 17th Annual ENETSConcerence (2020)

Presenting Author:

Authors: Hackeng W, Geisenberger C, de Leng W, Morsink F, Vriens M,

Keywords: Methylation profiling, Neuroendocrine tumor, Machine Learning, Unknown Primary,

#1883 Utility of a Circulating NET mRNA Gene Signature for Defining Bronchopulmonary Neuroendocrine Neoplasia and Evaluating Disease Progression

Introduction: Bronchopulmonary NETs (BPNETs) exhibit indolent to aggressive behavior. Imaging, histology and biochemistry are limited in accurately defining malignancy or progression. A blood based NET multigene test is effective in diagnosing GEP-NET progression and therapy response.

Conference: 14th Annual ENETSConcerence (2017)

Presenting Author: Kidd M

Authors: Lewczuk A, Chung K, Kolasińska-Ćwikła A, Ćwikła J, Kidd M,

Keywords: NET,

#1574 Somatostatin Receptors Profile in Pulmonary NETs Associated with DIPNECH

Introduction: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare entity characterised histologically by the proliferation of neuroendocrine cells along the distal bronchiolar epithelium, associated with small tumourlets and usually found in association with pulmonary carcinoid tumour. This can be clinically silent or may be associated with symptomatic obstructive bronchiolitis.

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Fabre A

Authors: Ryan C, Fabre A, Di Capua D, Swan N, Power D,

Keywords: SSTR, DIPNECH, carcinoid,

#1571 Blood Gene Transcript Analysis Diagnoses Bronchopulmonary NETs and Identifies Progressive Disease

Introduction: Broncho-Pulmonary (BP) NETs are pulmonary neoplasms with indolent to aggressive behavior. Imaging, histology and biochemistry are limited in defining malignancy or progression

Conference: 13th Annual ENETSConcerence (2016)

Presenting Author: Lewczuk A

Authors: Lewczuk A, Chung K, Kolasińska-Ćwikła A, Cwikła J, Kidd M,

Keywords: PCR,